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| SP-Merrifield High Loaded Resin, MP |
| PRODUCT: |
| SP-Merrifield High Loaded Resin, MP, a highly cross-linked polystyrene resin functionalized with a chloromethyl end group. |
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| APPLICATIONS: |
- SP-Merrifield High Loaded Resin is a chloromethyl functional resin that can be used for direct immobilization of carboxylic acids including N-protected amino acids.
- SP-Merrifield High Loaded Resin may be employed as a linker for secondary amines and as a base resin to incorporate linkers using easy loading of phenols and thiophenols.
- A simple, highly effective method for removing triphenylphosphine and/or triphenylphosphine oxide from reaction mixtures with high-loading chloromethylated polystyrene, modified in situ with NaI, acts as a scavenger resin.
- SP-Merrifield High Loaded Resin has a highly cross-linked macroporous resin framework, hence it is not dependent on swelling to be effective, making it compatible with a broad range of solvents including highly polar solvents including DMF and acetonitrile.
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| PROPERTIES: |
Resin Type: Macroporous poly(styrene-co-divinylbenzene)
Loading: 3.8-4.1 mmol/g (based on chlorine analysis)
Bead Size: 330-1225 microns, 15-48 mesh (>90% within)
Compatible Solvents: DCM, DMF, THF, MeOH, and acetonitrile. |
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| REFERENCES: |
- Kang, S. K. et al. Tetrahedron Lett, 1998, 39, 3011.
- Kurth, M. J. et al. J. Org. Chem, 1994, 59, 5862.
- Merrifield, R. B. J. Am. Chem. Soc, 1963, 85, 2149.
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