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| SP - PIPERAZINE RESIN, MP |
| PRODUCT: |
| SP - Piperazine Resin, MP, a highly cross-linked polystyrene resin functionalized with a Piperazine end group. |
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| APPLICATIONS: |
- SP-Piperazine Resin is a polymer bound piperazine.
- This support amine has been developed to serve as a Knoevenagel catalyst.
- As the product is polymer-bound, it eliminates piperidine-derived by-products and reduces transesterification while using alcohol as a solvent.
- Recently, this resin was shown to be recyclable in the synthesis of benzopyrones using "resin capture" methodology.
- SP-Piperazine Resin has been found to be highly effective in FMOC deprotection in both aqueous and non-aqueous solutions.
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| PROPERTIES: |
Resin Type: Macro porous poly (styrene-co-divinylbenzene)
Loading: 2.8 – 3.2 mmol/g (Elemental nitrogen analysis)
Bead Size: 100 - 200 mesh |
| Typical Scavenging: |
3-5 equivalent of resin relative to the FMOC content, for a period of 12-16 hours, room temperature. |
| Compatible Solvents: |
Polar and non polar solvents, including aqueous solvents. |
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| REFERENCES: |
- Simpson, J. et al. Tetrahedron Lett. 40, 7031, (1999)
- Bhat, A.S. et al. J. Comb. Chem. 2, 597, (2000) Abstract
- Gu L., Wu Y. Y., Zhang Y. Z., et al., Journal of Molecular Catalysis A: Chemical, 2006, 263, 186
- Saravanamurugan S., Palanichamy M., Hartmann M., et al., Applied Catalysis A: General, 2006, 298, 8
- Matziari M., Nasopoulou M., Yiotakis A., Org. Lett., 2006, 8, 2317
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