|
|
|
| SP - THIO – SILICA |
| PRODUCT: |
| SP - Thio - Silica, a thiol-functionalized silica gel. |
| |
| APPLICATIONS: |
- SP-Thio-Silica has a silica supported thiol functional group.
- It is a robust metal scavenger for a variety of metals including Pd, Pt, Cu, Ag and Pb under a wide range of conditions.
- SP-Thio-Silica has been used in pharmaceutical processes up to the pilot plant scale.
- It is our most versatile metal scavenger and is the preferred metal scavenger for Pd (II), Cu, Ag, and Hg.
- Silica supported Thiol is a scavenger of electrophiles eg. Alkyl-, benzyl- and allyl- halides, acid chlorides, isocyanates.
|
| PROPERTIES: |
Colour: Off white powder
Category: Base and metal Scavenger
Loading: 1.0 - 1.2 mmol/g (based on Nitrogen, sulphur content)
Particle Size: Avg 40 – 62 um |
| Typical Scavenging: |
3-5 equiv relative to metal content, 1-4 h, room temperature |
| Compatible Solvents: |
Effective both in aqueous and non aqueous solutions. |
| |
|
|
| REFERENCES: |
- dv. Synth. Catal., 346 (2004) 889
- Org. Proc. Res. Dev., 13 (2009) 598
- Org. Proc. Res. Dev., 12 (2008) 540
- Chem. Commun., 13 (2000) 1145
|
| |
|
|
|
|
