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| SP - Thiophenol Resin, MP Fine |
| PRODUCT: |
| SP–Thiophenol Resin, MP - Fine is solid-supported thiophenol on a mixed bed of macroporous polystyrene and silicates. |
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| APPLICATIONS: |
- SP-Thiophenol Resin, MP - Fine is a versatile metal-scavenger for palladium, platinum, ruthenium, tin, copper and mercury.
- This metal scavenger is particularly useful for scavenging of residual palladium from palladium-catalyzed hydrogenation and coupling reactions including Suzuki, Buchwald, Stille, Heck, Kumada and Sonogashira.
- SP-Thiophenol Resin, MP - Fine is equally versatile for the scavenging of a range of alkylating agents including octyl bromide, cinnamyl chloride and benzyl bromide.
- Efficient scavenging of alkyl halides results in the presence of acid scavengers such as SP-DIEA and SP-Carbonate resin.
- Alternatively, potassium trimethylsilanolate may be used to convert SP-Thiophenol Resin, MP - Fine to its thiolate salt for effective scavenging.
- SP-Thiophenol Resin, MP - Fine is stable with long-term storage at 4 0C.
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| PROPERTIES: |
Resin Type: Mixed bed of Macroporous polystyrene and silicates
Loading: 2.5 – 2.4 mmol/g (based on elemental analysis)
Bead Size: 100-200 mesh (>90% within) |
| Typical Palladium Scavenging Conditions: |
3-5 equiv of the resin relative to palladium content, 8-12 h at ambient temperature |
| Typical alkyl halide Scavenging Conditions: |
2-3 equiv of the resin relative to electrophile at ambient temperature, 1-10 h. Conversion to the thiophenolate with potassium trimethylsilanolate (TMSOK) or use in conjunction with SP-DIEA (2 equiv) and SP-Carbonate (2 equiv) required |
| Compatible Solvents: |
DMF, THF, DCM, MeOH, EtOH, acetonitrile and water |
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| REFERENCES: |
1. Kobayashi, S. et al. Tetrahedron Lett, 1996, 37, 5569.
2. Barco, A. et al. Tetrahedron Lett, 1998, 39, 7591.
3. Roso, V. W. et al. Org Process Res & Dev. 1997, 1, 311.
4. Ishihara, K. et al. Chem Lett 2000, 1218. |
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