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| SP - TRIETHYLAMINE RESIN, MP |
| PRODUCT: |
| SP-Triethylamine Resin, MP, a highly cross-linked polystyrene resin functionalized with a triethylamine end group. |
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| APPLICATIONS: |
- SP-Triethylamine can be used in applications requiring a tertiary amine base and where the resin-bound ammonium salt by products are readily separated by filtration.
- Applications include a broad range of organic reactions: elimination, substitution, oxidation, reduction and addition reactions.
- One pot synthesis of amides, sulfonamides and carbamates can be effected using filtration as the only purification step, when SP-Triethylamine is used in conjunction with SP-Trisamine as a scavenger resin.
- SP-Triethylamine is very useful in making free base from other amine salts such as hydrochlorides and trifluoroacetates.
- SP-Triethylamine has a highly cross-linked macroporous resin backbone, hence it is not dependent on swelling to be effective, making it compatible with a broad range of solvents including highly polar solvents.
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| PROPERTIES: |
Resin Type: Macroporous Poly(styrene-co-divinylbenzene)
Loading: 3.6 - 3.4 mmol/g (based on acid-base titration)
Bead Size: 330-1225 microns, 15-50 mesh (>90% within) |
| Typical Scavenging: |
2-3 equiv relative to limiting reagent |
| Compatible Solvents: |
DCM, DMF, THF, MeOH, any non-acidic organic solvents, acetonitrile and water |
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| REFERENCES: |
- Bhattacharyya, S.; Fan, L.; Vo, L.; Labadie, J. Combi Chem & High Throughput Screen, 2000, 3, 117.
- Caldereli, M.; Habermann, J.; Ley, S. V. Bioorg Med Chem Lett, 1999, 9, 2049.
- Conti, P.; Demont, D.; Cals, J.; Ottenheijm, H. C. J.; Leysen, D. Tetrahedron Lett 1997, 38, 2915.
- Booth, R. J.; Hodges, J. C. J. Am. Chem. Soc 1997, 119, 4882.
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